you know, im with mike on this one, ie 12 volts seems simply a lot safer, given all the 'stuff' that can accidentally occur.
low voltage means, if it does get wet or crossed or grounded, little happens. certainly a lot less than 110 no less 220. and, lets face it, eventually all of us end up crossing a wire from time to time, regardless of how careful we might try to be. this alone should be given weight. I understand a strand of xmas lights is too cheap to pass on, well.....maybe. (FWIW I DID try this indoors just last month, using a warm white xmas led strand on my n scale mainstreet buildings, all in a line.....didn't like the uniform look so I reconsidered.
outside I run 12 volts, and, I have a very wonky system, as I put my layout up and then change things every 2-3 years. as such, all of my lighting is 'modular', ie everything can be plugged and unplugged, and I run extension cords (heavy gauge speaker wire) to each building or distribution box powering a few buildings, (or street lights, yard lights, water crane, telephone booths ad nauseum).
I use those 9 v battery connectors on 1: building interiors; 2: lengths of wires -one end with 9v other end into 12 v distributions box powered by a dedicated train transformer-you could/should use one indoors and run a length outside to your own distribution box. Using a tran transformer allows me to dial in the brightness as well, which is really helpful-gives longer life and eliminates 'nuclear melt down' brightness.
In essence, this is simply creating your own power outlet in a multi connector terminal distribution box, like LGB sold, and then using several extension cords to each building, or sometimes multiple buildings connected to another distribution box.
if you substitute LEDs for incandescent bulbs, you can 'gang' a lot of bulbs with little draw on the wiring.
recently, I purchased on ebay, courtesy someone here, a large bunch of connector/plugs-akin to those which LGB used on its most modern coach lighting connections-