Thought I'd update on how we're using this method. We're screwing every 3 lengths of PECO flex together and then leaving a regular unscrewed fishplate. We then have (depending on ease of access to solder) either bonded the 4 length or have jumper wires feeding. to connect the wire to the screw we're using ring crimps which are crimped and then soldered. the PECO accounts for around two thirds of our track the rest of PIKO which we use clamps on and jumper wires.
I have to say I consider myself to be capable with a soldering iron and have never had a problem soldering bonding wires into code 250 or code 332 (I only use a 100w iron... though it does have a thick neck and tip) however using the screws is very quick and with a new drill bit even getting through the nickle silver PECO is fairly easy. Drilling at an angle as suggested by Neil seems the way to go too!