Slaters wheels, whilst very good, have a significantly smaller flange profile so you need good trackwork.
I think it's more a question of not using tight radius track.
Almost all my stock has much smaller flanges than LGB, and my track laying skills are on a par with my photography
but I rarely have derailments
Usually, if I have a troublesome truck, it's due to a lack of lubrication, either axlebox or bogie pivot. What is clear, for reliable running, is that the axles need to be free to slide from side to side a little bit, as well as to spin freely. Don't ask me why, as all I know is - 'cos it does.'